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A Study to Assess the Safety and Tolerability of BMS-986525 Alone and in Combination With Nivolumab in Participants With Relapsed/Refractory Small Cell Lung Cancer

RECRUITINGPhase 1/2Sponsored by Bristol-Myers Squibb
Actively Recruiting
PhasePhase 1/2
SponsorBristol-Myers Squibb
Started2025-02-03
Est. completion2029-04-23
Eligibility
Age18 Years+
Healthy vol.Accepted
Locations5 sites

Summary

The purpose of this study is to assess the safety and tolerability of BMS-986525 alone and in combination with Nivolumab in participants with Relapsed/Refractory Small Cell Lung Cancer

Eligibility

Age: 18 Years+Healthy volunteers accepted
Inclusion Criteria

* Participants must have histologically or cytologically documented relapsed/refractory small cell lung cancer (R/R-SCLC).
* Participants must have received at least 1 platinum-based chemotherapy regimen as per locally approved drug labels and institutional guidelines.
* In countries where standard of care first line systemic treatment includes platinum containing chemotherapy in combination with anti-PD-(L)1 therapy, it is required that participants have progressed on, are ineligible for or not have access to an anti-PD- (L)1 therapy.

Exclusion Criteria

* Participants must not have any untreated CNS metastases.
* Participants must not have an active, known or suspected autoimmune disease.
* Participants must not have had a prior organ or tissue allograft.
* Other protocol-defined Inclusion/Exclusion criteria apply.

Conditions3

CancerLung CancerRelapsed/Refractory Small Cell Lung Cancer

Locations5 sites

Michigan

1 site
Local Institution - 0011
Detroit, Michigan, 48201
Site 0011

New York

1 site
Local Institution - 0026
Buffalo, New York, 14263
Site 0026

North Carolina

1 site
Local Institution - 0005
Durham, North Carolina, 27710
Site 0005

Ohio

1 site
Local Institution - 0004
Cleveland, Ohio, 44106-5066
Site 0004

Tennessee

1 site
SCRI Oncology Partners
Nashville, Tennessee, 37203
Melissa Johnson, Site 0006615-329-7274

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Trial data from ClinicalTrials.gov. Trial status and eligibility can change — verify directly with the study contact or on ClinicalTrials.gov.

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