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Oral Melatonin Versus Oral Pregabalin on Postoperative Pain and Anxiety Following Spine Surgery

RECRUITINGN/ASponsored by Tanta University
Actively Recruiting
PhaseN/A
SponsorTanta University
Started2026-01-17
Est. completion2027-06-01
Eligibility
Age21 Years – 60 Years
Healthy vol.Accepted
View on ClinicalTrials.gov →

NCT07344467

Summary

This study aims to compare the efficacy of using Melatonin versus Pregabalin on postoperative pain and anxiety after spine surgeries.

Eligibility

Age: 21 Years – 60 YearsHealthy volunteers accepted
Inclusion Criteria:

* Patients aged 21-60 years old.
* Both sexes.
* Patients of American Society of Anesthesiologists (ASA) physical status I \& II.
* Undergoing elective spine surgery.

Exclusion Criteria:

* Patient refusal.
* History of allergic reactions to melatonin or pregabalin.
* Patients with cardiovascular disease (ischemic heart disease, Heart Failure, Arrythmia, Heart Block).
* Patients with kidney disease with (plasma creatinine level \> 1.5mg/dl).
* Patients with liver disease with (aspartate transaminase, alanine transaminase, and bilirubin levels more than twice the upper limit of normal).
* Psychological and cognitive disorders; dementia; major depression.
* Circadian rhythm disorders such as chronic fatigue syndrome and drowsiness.

Conditions6

AnxietyMelatoninOralPostoperative PainPregabalinSpine Surgery

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