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Electrophysiology-based DBS Programming for PD

RECRUITINGN/ASponsored by University of Florida
Actively Recruiting
PhaseN/A
SponsorUniversity of Florida
Started2026-01-15
Est. completion2027-01-15
Eligibility
Age21 Years – 89 Years
Healthy vol.Accepted
Locations1 site
View on ClinicalTrials.gov →

NCT07348705

Summary

Deep brain stimulation (DBS) effectively alleviates motor symptoms in Parkinson's disease (PD). However, current programming is manual and time-consuming. This study will evaluate physiology-based programming using local field potentials (LFPs) to identify optimal stimulation parameters. Specifically, DBS contact selection based on beta power and a broad-band approach will be compared with conventional clinician-based programming.

Eligibility

Age: 21 Years – 89 YearsHealthy volunteers accepted
Inclusion Criteria:

* Patients with a diagnosis of idiopathic PD fulfilling the Movement Disorder Society Clinical Diagnostic Criteria for PD
* DBS implantation with the Percept DBS device (Medtronic, USA) for the treatment of motor symptoms
* Ability to give informed consent for the study
* Willingness to do this study at the time of the initial programming session
* Age 21 to 89 years old

Exclusion Criteria:

* Inability to comply with the study protocol
* Atypical Parkinsonism
* Any personality or mood symptoms that study personnel believe will interfere with the study requirements

Conditions2

Parkinson's DiseaseParkinson's Disease (PD)

Locations1 site

Norman Fixel Institute for Neurological Diseases
Gainesville, Florida, 32608
Hikaru Kamo, MD, PhDHikaru.Kamo@neurology.ufl.edu

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