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Combination of Nerve Blocks and Local Infiltration Analgesia in Knee Arthroplasty

RECRUITINGPhase 4Sponsored by Region Skane
Actively Recruiting
PhasePhase 4
SponsorRegion Skane
Started2026-03-05
Est. completion2027-03-01
Eligibility
Age18 Years+
Healthy vol.Accepted
View on ClinicalTrials.gov →

NCT07350252

Summary

The aim of this clinical randomized trial is to compare local infiltration analgesia (LIA) alone versus the combination of LIA with saphenous nerve (SN) block, block of the nerve to vastus medialis (NVM), and anterior femoral cutaneous nerve (AFCN) block in participants undergoing total knee arthroplasty (TKA). The primary outcome is pain intensity, measured using the Numerical Rating Scale (NRS) at multiple time points after surgery. Secondary outcomes include opioid consumption, time to mobilization, postoperative nausea and vomiting, length of hospital stay, neurological complications and differences in opioid consumption and NRS pain scores between general and spinal anesthesia.

Eligibility

Age: 18 Years+Healthy volunteers accepted
Inclusion Criteria:

-Undergoing primary unilateral total knee arthroplasty

Exclusion Criteria:

* Pregnancy
* Coagulopathy or other bleeding disorder that precludes regional anesthesia
* Allergy to local anesthetics
* Inability to understand spoken and written Swedish
* Unwillingness to participate in the study

Conditions2

ArthritisOsteo Arthritis of the Knee

Interventions1

Ropivacain 5 mg/ml + Clonidine

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Trial data from ClinicalTrials.gov. Trial status and eligibility can change — verify directly with the study contact or on ClinicalTrials.gov.

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