Postoperative Acute Kidney Injury in Children Undergoing Major Non-cardiac Surgery

Summary

This project aims to conduct an international, prospective, multicentre, observational study to determine the incidence of Postoperative Acute Kidney Injury (PO-AKI) in hospitalized children after noncardiac surgery. Urinary biomarkers are intended to be evaluated as predictors of PO-AKI in the same subjects. The study employs modern standardized classifications for AKI to comprehensively address the issue of PO-AKI in children. Describing the incidence and identifying risk factors for PO-AKI will play a crucial role in developing preventive strategies aimed at reducing associated mortality and morbidity. Furthermore, investigating the relationship between urinary biomarkers of renal injury and PO-AKI will provide valuable insights into assessing postoperative renal function in paediatric patients, especially when repeated blood sampling is not feasible.

Eligibility

Inclusion Criteria:

* Elective, urgent or emergency in-patient major non-cardiac surgical procedures performed under general anaesthesia with or without regional analgesia with a planned procedure duration of at least 60 minutes.
* Paediatric patients (0-16 years old)

Exclusion Criteria:

* Declined participation.
* Ongoing renal replacement therapy
* Acute Kidney Injury (according to KDIGO)
* Known chronic kidney disease
* Procedure involving surgery of the kidney
* Procedures requiring clamping of blood flow to or from the kidney
* Body weight \<2kg
* Procedure involving contrast administration
* Established rhabdomyolysis (CK-levels \>1500 U/L)

Conditions2

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