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Multimodal Analysis of Endomyocardial Biopsies

RECRUITINGSponsored by University Hospital, Essen
Actively Recruiting
SponsorUniversity Hospital, Essen
Started2025-10-27
Est. completion2028-09-30
Eligibility
Age18 Years+
Healthy vol.Accepted
View on ClinicalTrials.gov →

NCT07359690

Summary

The goal of this observational study is to pursue a multimodal approach to identify the molecular signatures and immune signalling molecules of various myocardial diseases and thereby contribute to improving diagnosis and therapy. The main aim is: -Identification of molecular profiles (e.g., proteome, lipidome, metabolome) and immune signalling profiles that are specifically associated with different myocardial diseases and the post-heart transplantation course. Participants already receiving an endomyocardial biopsy as part of their regular medical care will be enrolled. An additional biopsy sample will be taken for the above mentioned research.

Eligibility

Age: 18 Years+Healthy volunteers accepted
Inclusion Criteria:

* Patients aged \>18 years with a clinical indication for endomyocardial biopsy.
* Patients capable of providing informed consent who have signed the consent form for participation in the study.

Exclusion Criteria:

* Patients without a clinical indication for endomyocardial biopsy (EMB).
* Pregnant individuals.
* Patients incapable of providing informed consent.
* Women of childbearing potential who are not using adequate contraception.

Conditions8

Amyloidosis CardiacCardiomyopathiesDilated Cardiomyopathy (DCM)Heart DiseaseHeart TransplantationHypertrophic Cardiomyopathy (HCM)Myocarditis, PericarditisSarcoidosis of the Heart

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