Early Detection of Selected Neuropathologies in Motor Vehicle Drivers

Summary

This study aims to develop accessible methods for the early detection of selected neuropathologies in drivers, focusing on multiple sclerosis and Parkinson's disease. The primary objective is to identify clinical tests that correlate with outcomes from the Vienna Test System (VTS), thereby enabling early diagnosis without the need for complex neurological or neuropsychological assessments. Findings could improve the effectiveness of routine driver medical check-ups and inform future modifications to Czech traffic law to enhance road safety.

Eligibility

Inclusion Criteria:

* Person after signing informed consent.
* After meeting the valid diagnostic criteria for the given neurological diagnosis.
* Possession of a valid driver's license and proof of active driving.
* Age limit 18 - 85 years.

Exclusion Criteria:

* Proven diagnosis of dementia based on a current psychological examination (MMSE 24 points or less).
* Diagnosis of a disease or condition that, according to Czech Law. No. 277/2004 Coll., on medical fitness to drive motor vehicles, as amended (especially Law No. 204/2025 Coll.), prevents or significantly limits the ability to drive a motor vehicle safely (e.g. dementia, epilepsy, severe disorders of consciousness).
* Age less than 18 years.
* Age more than 85 years.
* In the second cohort (patients with Multiple Sclerosis), proven and treated relapse in the last 6 weeks before inclusion in the study.
* In the MS cohort, current EDSS \> 6.5 points.
* For the PD cohort, the current Hoehn and Yahr scale score is greater than or equal to 4.
* For both cohorts, evidence of parainfectious deterioration as demonstrated by laboratory testing.

Conditions2

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