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Decoupling Immunotherapy Toxicity and Cancer Response

RECRUITINGSponsored by M.D. Anderson Cancer Center
Actively Recruiting
SponsorM.D. Anderson Cancer Center
Started2026-01-09
Est. completion2028-06-30
Eligibility
Age18 Years+
Healthy vol.Accepted
Locations1 site

Summary

This study is a novel evaluation of cardiotoxicity after ICI therapy based on traditional CV risk factors with the addition of metabolomic profiles, epigenetic aging, and CHIP. It is not an extension of previous work in ICI therapy.

Eligibility

Age: 18 Years+Healthy volunteers accepted
Inclusion Criteria:

1. Age ≥ 18 years
2. Plan to start immune checkpoint inhibitor for cancer therapy

Exclusion Criteria:

1. No baseline blood collection prior to initiation
2. At time of evaluation not determined to be a good candidate for evaluation of outcome events by the principal investigator

Conditions3

CancerCardiovascularTumor

Locations1 site

The University of Texas M. D. Anderson Cancer Center
Houston, Texas, 77030
Nicolas Palaskas, MD832-750-1109nlpalaskas@mdanderson.org

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