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Comparison of IVF Outcomes Between PPOS and Antagonist Protocols in Women With PCOS

RECRUITINGN/ASponsored by Hanoi General Hospital (Vietnam)
Actively Recruiting
PhaseN/A
SponsorHanoi General Hospital (Vietnam)
Started2026-01-20
Est. completion2027-06-30
Eligibility
Age18 Years – 40 Years
SexFEMALE
Healthy vol.Accepted
View on ClinicalTrials.gov →

NCT07394530

Summary

This study aims to compare the outcomes of two ovarian stimulation protocols used in in vitro fertilization (IVF): the progestin-primed ovarian stimulation (PPOS) protocol and the GnRH antagonist protocol.

Eligibility

Age: 18 Years – 40 YearsSex: FEMALEHealthy volunteers accepted
Inclusion Criteria:

* Women aged 18-40 years
* Diagnosed with polycystic ovary syndrome (PCOS) according to the modified Rotterdam criteria (2004) (≥2 of 3: oligo/anovulation, hyperandrogenism, or polycystic ovarian morphology on ultrasound)
* Indicated for in vitro fertilization (IVF) due to PCOS alone or PCOS with other infertility factors (e.g., tubal factor, previous failed IUI)
* Eligible for controlled ovarian stimulation for IVF
* Husband/partner with normal sperm parameters or mild to moderate oligoasthenoteratozoospermia (OAT)
* Willing and able to provide written informed consent and comply with study procedures.

Exclusion Criteria:

* Uterine abnormalities that may impair implantation or pregnancy outcomes, including congenital uterine malformations, large fibroids distorting the uterine cavity, adenomyosis, or severe intrauterine pathology.
* History of major ovarian or uterine surgery affecting ovarian reserve or uterine structure (e.g., ovarian cystectomy, endometriosis surgery, myomectomy, unilateral oophorectomy)
* History of recurrent pregnancy loss (≥3 spontaneous miscarriages)
* Known chromosomal abnormalities in either partner
* Inability to adhere to study protocol or follow-up procedures

Conditions3

CancerFemale InfertilityPolycystic Ovary Syndrome (PCOS)

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