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Impact of Thyroid Hormones on Human Glucose and Energy Metabolism

RECRUITINGN/ASponsored by University of Ulm
Actively Recruiting
PhaseN/A
SponsorUniversity of Ulm
Started2026-02-04
Est. completion2031-02
Eligibility
Healthy vol.Accepted
View on ClinicalTrials.gov →

NCT07410637

Summary

The goal of this clinical trial to clarify the impact of changes in thyroid hormone levels on glucose and lipid metabolism. Patients will be included in whom thyroid hormone levels are intentionally changed by treatment. In patients with Graves' disease, thyroid hormone levels will be lowered using medication, while in patients with thyroid cancer, thyroid hormone levels will be raised using medication. Oral glucose tolerance tests will be performed before treatment and at two time points after treatment begins to assess metabolic effects.

Eligibility

Healthy volunteers accepted
Inclusion Criteria:

* patients with initial diagnosis of graves disease OR
* patients with initial diagnosis of thyroid carcinoma

Exclusion Criteria:

* contraindications for oral glucose tolerance test
* Diabetes mellitus
* Fasting glucose level ≥ 200 mg/dL
* Exogenous insulin administration with action at the time of the test
* Current disease with activation of stress hormones
* Post-aggressive metabolism
* Acute infectious disease

Conditions3

CancerGraves DiseaseThyroid Cancer

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Trial data from ClinicalTrials.gov. Trial status and eligibility can change — verify directly with the study contact or on ClinicalTrials.gov.

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