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Response to Neoadjuvant Treatment in Locally Advanced Thyroid Cancer

RECRUITINGSponsored by Fujian Medical University
Actively Recruiting
SponsorFujian Medical University
Started2025-12-23
Est. completion2028-12-31
Eligibility
Age14 Years – 80 Years
Healthy vol.Accepted
View on ClinicalTrials.gov →

NCT07419932

Summary

This multicenter observational study aims to evaluate the safety and efficacy of neoadjuvant therapy in patients with locally advanced thyroid cancer, focusing on imaging, biochemical, and pathological responses, as well as short-term surgical outcomes and long-term prognosis.

Eligibility

Age: 14 Years – 80 YearsHealthy volunteers accepted
Inclusion Criteria:

* Age ≥ 14 years at enrollment.
* Eastern Cooperative Oncology Group (ECOG) performance status of 0-2.
* Histologically or cytologically confirmed thyroid carcinoma, including differentiated thyroid carcinoma (DTC), medullary thyroid carcinoma (MTC), poorly differentiated thyroid carcinoma (PDTC), and anaplastic thyroid carcinoma (ATC).
* LATC defined as clinical stage T4N0-1 at baseline, as confirmed by a multidisciplinary thyroid oncology board.
* For patients with distant metastasis, the potential benefit from surgical intervention must be documented by the treating team.
* Presence of at least one measurable lesion, according to Response Evaluation Criteria in Solid Tumors (RECIST) version 1.1.
* Normal function of major organs.
* Written informed consent obtained.

Exclusion Criteria:

* Patients who refuse tumor tissue biopsy or surgery.
* Prior thyroid or major neck surgery.
* History of other treatments for cancer, including surgery, chemotherapy, radiotherapy, or molecular targeted therapy, that may affect the current treatment plan.
* Concurrent active malignancies.
* Uncontrolled systemic diseases, including diabetes, hypertension, etc.
* Pregnancy or breastfeeding.

Conditions3

CancerThyroid CancerThyroid Neoplasms

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