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Cryoneurolysis Prior to Total Knee Arthroplasty (CRYO-TKA Trial)

RECRUITINGN/ASponsored by Attikon Hospital
Actively Recruiting
PhaseN/A
SponsorAttikon Hospital
Started2026-01-02
Est. completion2027-12-31
Eligibility
Age18 Years+
Healthy vol.Accepted
View on ClinicalTrials.gov →

NCT07425457

Summary

Approximately 20-30% of patients experience persistent pain after a Total Knee Arthroplasty (TKA). This study investigates whether percutaneous cryoneurolysis of genicular nerves can reduce pain and improve physical function when performed at least 24 hours before surgery. Participants will be randomized to receive either the cryoneurolysis procedure + TKA or TKA only. Results will be tracked for 6 months to see if the intervention improves long-term recovery and quality of life.

Eligibility

Age: 18 Years+Healthy volunteers accepted
Inclusion Criteria:

* Adults ≥18 years undergoing primary TKA for osteoarthritis.
* Cognitively normal and able to self-assess pain and function.
* Provide written informed consent.

Exclusion Criteria:

* Cancer-related knee pain.
* Neurological, psychiatric, or medical conditions interfering with assessment.
* Chronic opioid users.

Conditions7

ArthritisArthroplastyChronic PainGenicular NervesKnee Arthritis, OsteoarthritisKnee Arthroplasty, TotalReplacement Material

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