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Ventilation and Perfusion in Asthmatics

RECRUITINGPhase 4Sponsored by University of Miami
Actively Recruiting
PhasePhase 4
SponsorUniversity of Miami
Started2026-04-27
Est. completion2028-04
Eligibility
Age18 Years – 75 Years
Healthy vol.Accepted
Locations1 site
View on ClinicalTrials.gov →

NCT07426458

Summary

Assess regional changes to perfusion and ventilation from inhaled corticosteroid (ICS) and Fast-acting beta-antagonist (FABA) among adult asthmatics using radiographically derived estimates of regional ventilation (V-distribution), ventilation defect percentage (VDP), and ventilation heterogeneity (VH).

Eligibility

Age: 18 Years – 75 YearsHealthy volunteers accepted
Inclusion Criteria:

* Physician diagnosis of asthma
* Baseline Forced Expiratory Volume in 1 Second (FEV1) \< 80% of predicted, with reversibility (10%) on post-bronchodilator spirometry
* Adults, 18-75 years of age
* Long-term inhaled controller medication consisting of or including an Inhaled corticosteroids (ICS) at a steady dose for at least 3 months before enrollment

Exclusion Criteria:

* Current cigarette smoking or a past history of \>10 pack-year smoking
* Current nicotine vaping
* Pregnant and breast-feeding women
* Respiratory infection within 4 weeks of proposed study date
* Forced Expiratory Volume in 1 Second (FEV1) \< 50%
* Inhaled corticosteroids (ICS)/fast-acting beta agonist (FABA) intolerance
* Use of beta-blockers
* Use of systemic glucocorticosteroids or oral methyl-xanthines within 30 days of planned study visit.

Conditions1

Asthma

Interventions2

Albuterol sulfateAlbuterol-Budesonide

Locations1 site

University of Miami - Converge Miami
Miami, Florida, 33136
Tiffany Salcito305-243-2568tns93@med.miami.edu

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