"Detection and Follow-up of Coronary Lesions in HeFH (DESTINY-FH Study)"

Summary

This multicenter, non-randomized interventional study aims to assess coronary artery disease progression over 5 years in patients with genetically confirmed heterozygous familial hypercholesterolemia (HeFH), using coronary computed tomography angiography (CCTA). The primary endpoint is the visual evaluation of coronary stenosis using CAD-RADS v2.0, identifying changes between baseline (2018-2022) and study inclusion. The study will enroll 300 patients (100 protected, 200 non-protected) from La Pitié-Salpêtrière hospital and Saint Antoine Hospital (Paris). Participation lasts up to one week. Total study duration is 2 years, with extended follow-up through routine care data over 10 years.

Eligibility

Inclusion Criteria:

1. Patients with heterozygous familial hypercholesterolemia
2. Aged 30 to 60 years.
3. Patients who underwent a CAC score and a coronary CT angiogram at least 5 years ago, exclusively at the same imaging center (ICT de la Pitié Salpetrière).
4. Patient asymptomatic for exertional chest pain at the time of CCTA
5. Clinical examination performed
6. Beneficiary of a social protection scheme or entitled person (excluding AME)
7. Patient informed and consent form signed

Exclusion Criteria:

1. Patient under guardianship, or unable to give consent
2. Pregnancy, breast-feeding
3. Technical contraindication: weight \> 250 kg
4. Simultaneous participation in other interventional research involving the human body, or period of exclusion following previous research involving the human body still in progress.
5. Adults subject to a legal protection order
6. Contraindication to esmolol and/or atenolol
7. Only for patients who need to undergo a CT angiogram and a thoraco-abdominal-pelvic CT scan:

   * Renal insufficiency (LC\<60)
   * Unbalanced diabetes when acquiring a previous coronary angioscanner
   * Personal history of cardiovascular disease and myocardial infarction at the time of CCTA
   * Contraindication to iodinated contrast media
   * Patient having already had an adverse event (AE) during the acquisition of a prior coronary angioscanner

Conditions2

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