Postoperative Hypocalcemia After Thyroidectomy

Summary

This retrospective cohort study investigates predictors of postoperative hypocalcemia following thyroidectomy procedures at Minia University Hospital over a 10-year period (2014-2024). Postthyroidectomy hypocalcemia is one of the most common complications of thyroid surgery, affecting 20-50% of patients. The study aims to identify demographic, clinical, laboratory, and surgical factors associated with the development of both transient and permanent hypocalcemia. Results will inform risk stratification, patient counseling, and perioperative management strategies.

Eligibility

Inclusion Criteria:

* Adult patients aged 18 years or older at time of surgery
* Underwent thyroidectomy at Minia University Hospital
* Availability of medical records with complete surgical and postoperative data
* Documented serum calcium levels measured postoperatively
* Minimum follow-up of 6 months postoperatively or documented outcome status

Exclusion Criteria:

* Age less than 18 years at time of surgery
* Preoperative hypocalcemia (serum calcium \<8.0 mg/dL or ionized calcium \<1.0 mmol/L)
* Pre-existing parathyroid disorders (primary hyperparathyroidism, hypoparathyroidism, secondary or tertiary hyperparathyroidism)
* Chronic kidney disease Stage 3 or higher (estimated glomerular filtration rate \<60 mL/min/1.73m²)
* Malabsorption syndromes affecting calcium metabolism (celiac disease, inflammatory bowel disease,short bowel syndrome)
* Concurrent planned parathyroidectomy
* History of neck irradiation
* Chronic use of medications significantly affecting calcium metabolism (bisphosphonates, denosumab,cinacalcet, chronic corticosteroids)
* Incomplete medical records lacking essential data including surgical details, postoperative calcium levels,or follow-up data
* Patients lost to follow-up before 6-month endpoint without documented outcome status

Conditions6

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