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A Study of TORL-5-700 in Relapsed/Refractory Non Hodgkin's Lymphoma

RECRUITINGPhase 1/2Sponsored by TORL Biotherapeutics, LLC
Actively Recruiting
PhasePhase 1/2
SponsorTORL Biotherapeutics, LLC
Started2026-03-31
Est. completion2029-03-31
Eligibility
Age18 Years+
Healthy vol.Accepted
Locations6 sites
View on ClinicalTrials.gov →

NCT07439653

Summary

A Phase 1/2 study to evaluate safety, tolerability, and anticancer activity of TORL-5-700 as a monotherapy and in combination in R/R NHL

Eligibility

Age: 18 Years+Healthy volunteers accepted
Inclusion Criteria:

* Confirmed B-NHL, including but not limited to de novo DLBCL; FL, Grades 1 to 3A; MCL; transformed lymphoma (tFL, RT) and FL Grade 3B; MZL and MALT.
* Eastern Cooperative Oncology Group (ECOG) performance status less than or equal to 2.
* At least 1 measurable lesion per Lugano criteria.
* Tumor tissue is available.
* Adequate organ function

Exclusion Criteria:

* T-cell lymphoma
* CLL or SL
* Burkitt lymphoma and high-grade B-cell lymphoma
* CNS involvement
* Peripheral neuropathy \> Grade 2
* Uncontrolled medical conditions
* Viral infections

Conditions2

CancerHistologically Confirmed Relapsed or Refractory B-cell Non-Hodgkin Lymphoma

Interventions3

TORL-5-700TORL-5-700 at MTD/RP2DTORL-5-700 at MTD/RP2D in combination with another agent

Locations6 sites

Providence Medical Foundation
Fullerton, California, 92835
UCLA
Santa Monica, California, 90404
Stanford University
Stanford, California, 94305
University of Iowa Health Care
Iowa City, Iowa, 52242
Sarah Cannon Research Institute
Nashville, Tennessee, 37203

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Trial data from ClinicalTrials.gov. Trial status and eligibility can change — verify directly with the study contact or on ClinicalTrials.gov.

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