ANO31905 in Combination With Chemotherapy for CLDN18.2-Positive Locally Advanced Unresectable or Metastatic Pancreatic Cancer

Summary

The goal of this clinical trial is to assess the safety and efficacy of ANO31905 in combination with chemotherapy as the first-line treatment for subjects with CLDN18.2-positive locally advanced unresectable or metastatic pancreatic cancer.

Eligibility

Inclusion Criteria:

1. Males or females aged ≥ 18 at the time of signing the ICF;
2. Eastern Cooperative Oncology Group (ECOG) performance status score of 0-1;
3. Expected survival ≥ 3 months;
4. Histologically or cytologically confirmed diagnosis of pancreatic ductal adenocarcinoma;
5. At least one measurable lesion according to RECIST v1.1;
6. Tumor tissue samples are determined to be CLDN18.2-positive by immunohistochemistry (IHC) in the central laboratory;
7. Patients with sufficient organ function within 7 days before the first study dose;
8. Non-pregnant or -lactating women.

Exclusion Criteria:

1. Patients with other malignant tumors except pancreatic adenocarcinoma within 5 years before the first dose of the study treatment; Any previous systematic anti-cancer therapy
2. Any previous systematic anti-cancer therapy;
3. Previous treatment targeting CLDN18.2;
4. Patients with a history of active autoimmune disorders or autoimmune disorders requiring systemic treatment;
5. Patients with known hypersensitivity to any component or excipient of ANO31905, gemcitabine, and nanoparticle albumin-bound paclitaxel;
6. Patients with known metastases to the central nervous system;
7. Patients with severe cardiovascular and cardiovascular diseases;
8. Presence risks of thrombosis or bleeding;
9. Patients who have received attenuated live vaccines within 28 days before the first study dose or are expected to receive attenuated live vaccines during study treatment;
10. Patients with gastrointestinal diseases that are not suitable for enrollment as judged by the investigator;
11. Patients with other conditions that may place the patients at increased undue study-related risks.

Conditions2

Interventions3

Locations1 site

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