Nested Pilot Study Comparing Two Treatments to Reduce Type 2 Diabetes Risk in At-Risk Delawareans

Summary

This nested pilot Randomized Clinical Trial will determine whether the Diabetes Prevention Program (DPP) enhanced with evidence-based sleep health and time restricted eating interventions ("DPP++") is more effective than the DPP alone for improving metabolic and cardiovascular metrics in 40 overweight/obese adults with prediabetes.

Eligibility

Inclusion Criteria:

* Adults aged 18 years or older
* Prediabetes confirmed by blood test result within 12 months of enrollment, previous diagnosis of gestational diabetes mellitus (GDM), or positive screening for prediabetes based on the Prediabetes Risk Test
* BMI of 25 kg/m² or greater (23 kg/m² or greater for Asian Americans)

Exclusion Criteria:

* Age younger than 18 years
* BMI less than 25 kg/m² (less than 23 kg/m² for Asian Americans)
* No current diagnosis of prediabetes or gestational diabetes mellitus
* Prior diagnosis of type 1 or type 2 diabetes
* Pregnancy at the time of enrollment
* Development of a medical condition that, in the PI's judgment, could be exacerbated by the study interventions (e.g., eating disorder, severe sleep disorder)

Conditions2

Locations1 site

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