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Liquid Biopsy and Machine Learning for Early Colorectal Cancer, Adenomas, Lynch Cancers, and Residual Disease Detection

RECRUITINGSponsored by San Raffaele University
Actively Recruiting
SponsorSan Raffaele University
Started2024-01-01
Est. completion2031-01-15
Eligibility
Age18 Years+
Healthy vol.Accepted
View on ClinicalTrials.gov →

NCT07450612

Summary

This is an multicenter study that will test the diagnostic accuracy of a blood test (i.e., a liquid biopsy) for the diagnosis of colorectal cancer (CRC), advanced adenomas (AAs), as well as Lynch-syndrome associated cancers. Additionally, a pre-planned analysis will evaluate the use of this liquid biopsy as a tool for molecular residual disease monitoring purposes.

Eligibility

Age: 18 Years+Healthy volunteers accepted
Inclusion Criteria:

* All individuals included in the study need to have had a colonoscopy at the time of blood sampling.
* Received standard diagnostic and staging (as necessary) procedures as per local guidelines, and at least one sample was drawn before receiving any curative-intent treatment.
* Received standard pathological and endoscopic diagnosis and assessment for cohort assignment

Exclusion Criteria:

* Lack of informed consent
* Inflammatory bowel disease

Conditions20

Adenoma ColonAdenoma Colon PolypCancerColo-rectal CancerColon AdenomaColon DiseaseColon NeoplasmColorectal CancerEPCAM Gene MutationLYN Gene Mutation

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