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Glycocalyx and Oxidative Stress in Endothelial Function (Part 2)

RECRUITINGSponsored by Josip Juraj Strossmayer University of Osijek
Actively Recruiting
SponsorJosip Juraj Strossmayer University of Osijek
Started2025-10-01
Est. completion2029-09-30
Eligibility
Age18 Years+
Healthy vol.Accepted
View on ClinicalTrials.gov →

NCT07451873

Summary

The primary research objective of the project is to determine the role of eGC in microvascular reactivity in patients with coronary heart disease (CHD) before and after bypass grafting (cross-sectional study 2).The main objective of the project is to increase the excellence and interdisciplinarity of scientific work at MEFOS by connecting researchers from different scientific fields, improving conditions and resources for scientific work, and increasing international cooperation, in line with strategic objective 1: raising scientific excellence. The results of the project could provide pathophysiological insight into the development and maintenance of endothelial dysfunction in CVD, as well as identify new biomarkers for CVD.

Eligibility

Age: 18 Years+Healthy volunteers accepted
Inclusion Criteria:

* adult patients of both sexes over 18 years of age
* Caucasian
* undergoing elective coronary artery bypass grafting (CABG)
* provided written informed consent

Exclusion Criteria:

* emergency surgery
* sepsis or severe systemic inflammation before surgery
* severe renal or hepatic insufficiency
* immunosuppression
* serious comorbidities (e.g., active cancer)
* therapies that could affect oxidative stress (e.g., high doses of corticosteroids)

Conditions2

Coronary Heart DiseaseHeart Disease

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