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ECG Findings in Methamphetamine Use

RECRUITINGSponsored by Elazığ Mental Health and Diseases Hospital
Actively Recruiting
SponsorElazığ Mental Health and Diseases Hospital
Started2025-04-07
Est. completion2026-04-06
Eligibility
Age18 Years – 65 Years
SexMALE
Healthy vol.Accepted
View on ClinicalTrials.gov →

NCT07459244

Summary

This prospective cohort study aims to examine and compare electrocardiogram (ECG) parameters in subjects diagnosed with Methamphetamine Use Disorder (MUD) and Methamphetamine-Induced Psychotic Disorder (MP) during inpatient psychiatric treatment. ECG findings at hospital admission and during remission prior to discharge will be evaluated and compared between groups. The study also aims to determine whether methamphetamine-induced psychosis is associated with greater ECG abnormalities and increased cardiac risk compared to methamphetamine use without psychosis.

Eligibility

Age: 18 Years – 65 YearsSex: MALEHealthy volunteers accepted
1. For Methamphetamine Use Disorder (MUD) Group:

   \*Inclusion Criteria:
   * Diagnosis of MUD according to DSM-5-TR
   * Medication-free for at least one month prior to admission
   * Age ≥ 18 years and \<65 years
   * Provided informed consent

   For Methamphetamine Use Disorder (MUD) Group:

   \*Exclusion Criteria:

   • Hypertension
   * Diabetes mellitus
   * Chronic kidney disease
   * Rheumatoid arthritis
   * Systemic lupus erythematosus
   * Cardiac illness
   * Severe neurological disorders
   * Immunological or systemic illness
   * Primary psychiatric disorders other than MUD
   * Alcohol use disorder
2. For Methamphetamine-Induced Psychotic Disorder (MP) Group:

   \*Inclusion Criteria:
   * Diagnosis of MP according to DSM-5-TR
   * Medication-free for at least one month prior to admission
   * Age ≥ 18 years and \<65 years
   * Provided informed consent

   For Methamphetamine-Induced Psychotic Disorder (MP) Group:

   \*Exclusion Criteria:
   * Hypertension
   * Diabetes mellitus
   * Chronic kidney disease
   * Rheumatoid arthritis
   * Systemic lupus erythematosus
   * Cardiac illness
   * Severe neurological disorders
   * Immunological or systemic illness
   * Primary psychiatric disorders other than MP
   * Alcohol use disorder
3. For Healthy Control Group:

   \*Inclusion Criteria:
   * No psychiatric diagnosis
   * No systemic or immunological illness
   * Medication-free for at least one month
   * Age ≥ 18 years and \<65 years
   * Provided informed consent

   For Healthy Control Group:

   \*Exclusion Criteria:

   • Hypertension
   * Diabetes mellitus
   * Chronic kidney disease
   * Rheumatoid arthritis
   * Systemic lupus erythematosus
   * Cardiac illness
   * Severe neurological disorders
   * Immunological or systemic illness
   * Primary psychiatric disorders other than schizophrenia
   * Alcohol/drug/substance use

Conditions3

Heart DiseaseMethamphetamine Induced PsychosisMethamphetamine Use Disorder

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