|

The Effects of High-dose Vitamin B6 on Depression and Anxiety Symptoms

RECRUITINGN/ASponsored by University of Reading
Actively Recruiting
PhaseN/A
SponsorUniversity of Reading
Started2026-02
Est. completion2026-11
Eligibility
Age18 Years – 41 Years
Healthy vol.Accepted
View on ClinicalTrials.gov →

NCT07469462

Summary

This clinical trial investigates the effects of Vitamin B6 supplementation on neural inhibition using electroencephalography (EEG), in relation to depression and anxiety symptoms in participants from the general population with a relatively high level of symptoms at baseline. Researchers will compare a placebo group to high-dose Vitamin B6 to test the hypothesis that Vitamin B6 moves the excitation/inhibition balance towards inhibition.

Eligibility

Age: 18 Years – 41 YearsHealthy volunteers accepted
Inclusion Criteria:

* Over 18 years of age and under 41
* Mild to moderate anxiety and/or depression
* Normal or corrected to normal vision

Exclusion Criteria:

* not taking daily dietary supplement containing \>2 mg Vitamin B6
* not taking medication that is a GABA agaonist (our team will check this with you)
* not be pregnant
* no medical history of epilepsy
* no medical history of peripheral neuropathy
* not taking the antibiotic Seromycin (prescribed for tuberclosis or urinary tract infection)
* no history of brain injury or recent concussion

Conditions3

AnxietyDepressionNeural Inhibition

Interventions2

Placebo SupplementationPyridoxal-5'-Phosphate supplement

Browse More Trials

Depression trialsAnxiety trials

Trial data from ClinicalTrials.gov. Trial status and eligibility can change — verify directly with the study contact or on ClinicalTrials.gov.

This site does not provide medical advice. Always consult your doctor before considering enrollment in a clinical trial. Learn more on our About page.