Skin Involvement in Dupuytren Surgical Treatment Outcome

Summary

Palmar skin is often retracted in Dupuytren disease (DD), making surgical management challenging and skin-preserving surgery difficult. Based on clinical experience in DD surgery and outcome, it is suspected that recurrence may be associated with such retracted skin. Possibly, this is due to presence and persistence of aligned myofibroblasts (MF), fixed to the deepest dermal layers. This interventional study aims to investigate the pathophysiological involvement of palmar skin in Dupuytren disease, and its implications for prognostics and treatment.

Eligibility

Inclusion Criteria:

1. Voluntary written informed consent of the participant or their legally authorized representative has been obtained prior to any screening procedures.
2. Patients ≥ 18 years old, diagnosed with primary Dupuytren disease.
3. Patients must be scheduled for microfasciectomy.

Exclusion Criteria:

1. Earlier Dupuytren surgery in the hand scheduled for microfasciectomy
2. Patient's unable to give a written participating consent.
3. Younger than 18 years of age.

Conditions2

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