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Small Bowel Capsule Endoscopy in Lynch Syndrome

RECRUITINGSponsored by Assistance Publique - Hôpitaux de Paris
Actively Recruiting
SponsorAssistance Publique - Hôpitaux de Paris
Started2025-06-16
Est. completion2026-06
Eligibility
Age18 Years+
Healthy vol.Accepted
View on ClinicalTrials.gov →

NCT07472686

Summary

The impact of small bowel (SB) capsule endoscopy (CE) on the screening (followed by diagnosis and treatment) of (pre)neoplastic lesions of the small bowel in Lynch syndrome (LS) patients is unknown. The iCARE4Lynch study is a retrospective cohort of patients carrying a pathogenic variant of the DNA mismatch repair gene (MMR) (MLH1, MSH2, MSH6, PMS2, EPCAM) who had had at least one SBCE for screening of small bowel (pre)neoplastic lesions between January 1st 2000 and December 31 2024.

Eligibility

Age: 18 Years+Healthy volunteers accepted
Inclusion Criteria:

* Patient carrying a pathogenic variant of the DNA mismatch repair gene (MMR) (MLH1, MSH2, MSH6, PMS2, EPCAM)
* Capsule endoscopy screening for (pre)neoplastic lesions of the small intestine
* No opposition to the reuse of healthcare data for research purposes

Exclusion Criteria:

* Absence of documented MMR gene variant
* Opposition to the study

Conditions5

CancerLynch SyndromeMMR MutationSmall Bowel AdenocarcinomaSmall Bowel Adenoma

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