Low-glucose/High-fat Intake Dietary Regimen as a Tool for Empowering Diagnostic Accuracy of 2-[18F]FDG PET/CT in Lepidic-predominant Growth Lung Adenocarcinoma

Summary

This study evaluates whether a 7-day ketogenic dietary regimen before 2-\[18F\]FDG PET/CT can improve the diagnostic accuracy of imaging in adults with suspected or histologically confirmed lepidic-predominant lung adenocarcinoma (LPA). LPA frequently shows low glucose metabolism and may yield false-negative FDG PET/CT results. Approximately 30 participants will undergo a tailored ketogenic diet for 7 days before PET/CT. Imaging results will be compared with histopathology and additionally assessed against literature-reported diagnostic performance and a matched retrospective institutional cohort.

Eligibility

Inclusion Criteria:

* Written informed consent.
* Age 18 years or older.
* CT evidence of a lung nodule suspicious for LPA or lung biopsy positive for LPA.
* Target nodule diameter at least 10 mm.
* ECOG performance status 0 to 2.
* Willingness and ability to adhere to a controlled ketogenic diet for 7 days.
* Ability to comply with study procedures and visit schedule.

Exclusion Criteria:

* Not suitable for prolonged imaging procedures.
* Renal failure.
* Type 1 diabetes mellitus.
* Pancreatitis.
* Severe dyslipidemia.
* Other malignancies that are progressing or required active treatment within the previous 3 years.
* Serious or unstable medical, psychiatric, or substance use disorders that could interfere with study participation.
* Pregnancy or breastfeeding.
* Refusal to participate

Conditions4

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