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Progel Platinum for Air Leak Reduction After VATS Lobectomy for NSCLC

RECRUITINGN/ASponsored by Fondazione del Piemonte per l'Oncologia
Actively Recruiting
PhaseN/A
SponsorFondazione del Piemonte per l'Oncologia
Started2026-02-27
Est. completion2027-02-27
Eligibility
Age18 Years – 99 Years
Healthy vol.Accepted
View on ClinicalTrials.gov →

NCT07479277

Summary

This multicenter randomized trial evaluates whether routine use of Progel Platinum surgical sealant on stapled fissure lines during VATS upper or lower lobectomy for NSCLC reduces pleural drainage duration compared with standard stapling alone. Secondary objectives include postoperative length of stay, incidence and duration of postoperative air leaks, residual pleural space, safety outcomes, and hospitalization costs.

Eligibility

Age: 18 Years – 99 YearsHealthy volunteers accepted
Inclusion Criteria:

* Age ≥18 years
* Written informed consent
* Planned VATS upper or lower lobectomy for NSCLC
* Minimally invasive thoracoscopic approach
* Middle lobectomy excluded

Exclusion Criteria:

* Induction radiochemotherapy or chemo-immunotherapy
* Severe COPD: GOLD 3 or higher
* Sleeve resection or extended resection involving other lobes/chest wall/pericardium, etc.
* Albumin intolerance/allergy
* Renal insufficiency
* Redo surgery
* Use of sealants/adhesives other than the study approach
* Expected extensive pleural adhesions

Conditions5

CancerLung CancerNSCLCNon Small Cell Lung CancerPostoperative Air Leak

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Trial data from ClinicalTrials.gov. Trial status and eligibility can change — verify directly with the study contact or on ClinicalTrials.gov.

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