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Exploratory Clinical Evaluation of Personalized Functional Profiling in GI Tumors: Predicting Drug Response in CRC and PDAC

RECRUITINGSponsored by Luxembourg Institute of Health
Actively Recruiting
SponsorLuxembourg Institute of Health
Started2026-09-11
Est. completion2029-09-30
Eligibility
Age18 Years+
Healthy vol.Accepted
View on ClinicalTrials.gov →

NCT07500259

Summary

The ColoPan study evaluates the scientific validity, reproducibility, and predictive performance of the Personalised Functional Profiling (PFP) platform in colorectal cancer and pancreatic ductal adenocarcinoma patients. It combines genomic sequencing with in vitro functional drug testing using patient-derived spheroids/organoids.

Eligibility

Age: 18 Years+Healthy volunteers accepted
Inclusion Criteria:

* Signed informed consent form
* ≥ 18 years of age
* Willing and able to comply with the protocol for the duration of the study, including data and sample collection
* Patient scheduled for surgery or biopsy (primary tumour or metastasis) PDAC

Exclusion Criteria:

* Female patient, pregnant, planning a pregnancy or breastfeeding.
* Known active Human Immunodeficiency Virus (HIV), Hepatitis B Virus (HBV), or Hepatitis C Virus (HCV) infection.
* Patient unable to understand and provide informed consent and has no family member representing him/her.
* Patients with any other life-threatening illness, significant organ dysfunction or any clinically relevant conditions that, according to the hospital physician, could compromise the patient's safety.

Conditions3

CancerColorectal CancerPDAC - Pancreatic Ductal Adenocarcinoma

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