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Integrating Digital Phenotypes and AI-Driven Cognitive-Behavioral Therapy: Advancing Precision Medicine in Depression Through Digital Medicine

RECRUITINGN/ASponsored by National Science and Technology Council, Taiwan
Actively Recruiting
PhaseN/A
SponsorNational Science and Technology Council, Taiwan
Started2025-06-01
Est. completion2027-06
Eligibility
Age18 Years – 75 Years
Healthy vol.Accepted
View on ClinicalTrials.gov →

NCT07500714

Summary

This project aims to integrate digital phenotyping and AI-driven iCBT into a comprehensive platform for MDD diagnosis and treatment in Taiwan. The study will explore dynamic, real-time behavioral and physiological markers to refine diagnostic classifications and optimize personalized therapeutic strategies.

Eligibility

Age: 18 Years – 75 YearsHealthy volunteers accepted
Inclusion Criteria:

* (1) Aged 18-75 years
* Diagnosis of major depressive disorder disorder (Based on Diagnostic Statistical Manual 5)
* 21-item Hamilton Depression Scale (HAMD21)\>17
* No changes in current psychiatric treatment for depression (e.g., no treatment, antidepressant medication, psychotherapy, or non-invasive brain stimulation) within the past four weeks, and
* Full competency to understand the study details and provide written informed consent

Exclusion Criteria:

* Scores of 5 ( Markedly ill), 6,(Severely ill), and 7 (Among the most extremely ill) according to the Clinical Global Impression Scale-Severity (CGI-S)
* Psychotic disorders, bipolar affective disorder, a substance use disorders in the past 6 months, active suicidal or homicidal ideation (per assessment or HAMD\>3)
* Unstable or active medical illness.

Conditions2

DepressionDepression - Major Depressive Disorder

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