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Prolonged Nasogastric Administration of Ketones in Decompensated Heart Failure

RECRUITINGPhase 4Sponsored by Institute for Clinical and Experimental Medicine
Actively Recruiting
PhasePhase 4
SponsorInstitute for Clinical and Experimental Medicine
Started2026-04-04
Est. completion2027-03-31
Eligibility
Age18 Years+
Healthy vol.Accepted
View on ClinicalTrials.gov →

NCT07527156

Summary

This study will evaluate the feasibility and safety of achieving therapeutic concentrations of beta-hydroxybutyrate using continuous infusion of D-beta-hydroxybutyrate monoester administered via a nasogastric tube in patients with acutely decompensated heart failure with reduced left ventricular ejection fraction.

Eligibility

Age: 18 Years+Healthy volunteers accepted
Inclusion Criteria:

* LVEF \<35%
* Acute heart failure with low cardiac output syndrome or cardiogenic shock

Exclusion Criteria:

* Severe liver failure
* Severe acidosis
* Inability to insert nasogastric tube
* Gastric paralysis / ileus
* Repeated vomiting
* Severe hypokalemia

Conditions6

Acute Heart Failure (AHF)Cardiogenic ShockHeart DiseaseHeart FailureKetone Body MetabolismKetones

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