Cardiopulmonary Exercise Testing in Lung Cancer Patients Before and During Oncological Treatment

Summary

Patients with lung cancer often have reduced physical fitness and coexisting health problems, which may limit their ability to tolerate oncological treatment. Standard resting lung and heart tests do not always reflect real-life physical capacity during everyday activities or physical effort. This observational study aims to assess cardiorespiratory fitness in patients with lung cancer before and during standard oncological treatment using cardiopulmonary exercise testing (CPET). CPET is a safe, supervised exercise test that provides objective information on how the heart, lungs, and muscles respond to physical effort. Participants with WHO/ECOG performance status 0-2 will undergo CPET before treatment initiation and again after the early phase of therapy or surgery. The results may help identify patients with reduced physiological reserve and support individualized monitoring during routine clinical care.

Eligibility

Inclusion Criteria:

* Age ≥ 18 years
* Histologically confirmed lung cancer (any stage)
* Qualified for standard oncological management (surgery and/or systemic therapy)
* WHO/ECOG performance status 0-2
* Ability to perform cardiopulmonary exercise testing (CPET)
* Written informed consent

Exclusion Criteria:

* Unstable ischemic heart disease
* Symptomatic cardiac arrhythmias
* Myocarditis or pericarditis
* Decompensated heart failure
* Active deep vein thrombosis
* Suspected aortic dissection or severe aortic stenosis
* Poorly controlled asthma
* Resting oxygen saturation ≤ 85% on room air
* Clinically relevant treatment-related adverse events above mild intensity (as applicable)
* Any medical condition that, in the investigator's opinion, precludes safe participation in CPET
* Withdrawal of informed consent

Conditions4

Browse More Trials