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A Longitudinal Cohort Study on the Changes of Physiological Mechanisms in Children After Biliary Tract Reconstruction

RECRUITINGSponsored by Wuhan Children's Hospital
Actively Recruiting
SponsorWuhan Children's Hospital
Started2025-05-01
Est. completion2035-04
Eligibility
Healthy vol.Accepted
View on ClinicalTrials.gov →

NCT07530354

Summary

Through observational studies, the long-term changes in liver function, metabolic state, immune response and other aspects of children after biliary tract reconstruction during their growth process were systematically explored. The risks of these long-term physiological changes on chronic diseases such as cardiovascular diseases, diabetic diseases and liver cirrhosis in adulthood, as well as their impacts on cognitive function, musculoskeletal health and other aspects were evaluated. How do early physiological changes affect a patient's long-term health? Are there any potential biomarkers that can predict future health outcomes? Based on the research results, preventive and intervention measures that are helpful in reducing the risk of long-term complications are proposed.

Eligibility

Healthy volunteers accepted
Inclusion Criteria:

* Healthy children matched by age and gender were selected as the control group

Exclusion Criteria:

* Combined with other serious diseases (such as cancer, autoimmune diseases), having obvious liver function abnormalities before surgery or being undergoing other major treatments.

Conditions2

CancerCholedochal Cyst

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