Links Between Self-awareness and Sociocognitive Processes in Neurodegenerative Diseases

Summary

This monocentric, non-interventional study (SELFSOC) investigates the relationship between self-awareness and social cognition in patients with behavioral variant frontotemporal dementia (bvFTD) and Alzheimer's disease (AD). The primary objective is to assess metacognitive efficiency related to social cognitive performance using a computerized facial emotion recognition task combined with confidence judgments. Metacognitive indices (including Mratio) will quantify the correspondence between subjective and objective performance. Thirty-four participants (17 bvFTD, 17 AD; age 50-80; MMSE ≥20) will complete two study visits involving tasks assessing emotion recognition, theory of mind, and memory.

Eligibility

Inclusion Criteria:

* Diagnosis of possible or probable behavioral variant frontotemporal dementia according to the Rascovsky 2011 criteria (DLFTvc group) OR
* Diagnosis of Alzheimer's disease according to the Jack 2018 criteria, including biomarkers (MA group)
* Mini-Mental State Examination (MMSE) ≥ 20
* Age: 50-80 years
* Sufficient reading and writing proficiency in French to enable completion of the study procedures, in the investigator's opinion

Exclusion Criteria:

* Moderate to severe language disorders: Confrontation naming (DO 40 scale) ≤ 32
* Inability to perform computerized tasks according to the investigator's opinion
* Other neurological disorders (including epilepsy, Lewy body disease, vascular dementia)
* Psychiatric comorbidities (bipolar disorder, schizophrenia, current major depressive episode)
* Uncorrected visual impairment

Conditions3

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