Continuous Versus Bolus Norepinephrine Administration to Treat Postinduction Hypotension

Summary

INDUCT-Multi is a multicenter randomized trial investigating whether continuous, compared to bolus, administration of norepinephrine during induction of general anesthesia reduces postinduction hypotension in high-risk non-cardiac surgery patients.

Eligibility

Inclusion Criteria:

We will include consenting patients ≥45 years scheduled for elective major non-cardiac surgery under general anesthesia with planned continuous intra-arterial blood pressure monitoring with a radial arterial catheter and with at least two of the following risk criteria for developing acute kidney injury:

* Age ≥65 years
* ASA physical status III or IV
* Chronic arterial hypertension
* Diabetes mellitus requiring medication
* Intra-abdominal surgery
* Preoperative renal insufficiency (serum creatinine ≥1.2 mg/dL)

Exclusion Criteria:

* Pregnancy
* Cardiac arrhythmia
* History of intracranial hemorrhage or intracranial aneurysm
* Clinical indication for continuous norepinephrine infusion during induction of general anesthesia (e.g., severe aortic valve stenosis, coronary artery disease, or heart failure)
* Patients who are unable to understand, read, and provide informed consent in German

Conditions2

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