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Prospective Prostate Cancer Infrastructure

RECRUITINGSponsored by Radboud University Medical Center
Actively Recruiting
SponsorRadboud University Medical Center
Started2026-09-01
Est. completion2030-09
Eligibility
Age18 Years+
SexMALE
View on ClinicalTrials.gov →

NCT07560748

Summary

The goal of this observational study is to collect detailed long-term real-world data and biomaterials from men with high-risk localized prostate cancer and synchronous metastatic hormone-sensitive prostate cancer. This will help to better understand how these patients are treated in daily practice, how treatments affect quality of life, and facilitate biomarker discovery. The infrastructure is also designed to enable future cohort multiple randomized controlled trials.

Eligibility

Age: 18 Years+Sex: MALE
Inclusion Criteria:

* Diagnosis of either: high-risk localized prostate cancer (any of the following: PSA \> 20 ng/mL, ISUP Grade Group 4 or 5, or clinical stage ≥ T2c); or metastatic prostate cancer confirmed by imaging (CT, bone scintigraphy, PSMA PET/CT, or (whole-body) MRI in combination with tumor markers (PSA)), or by biopsy of a metastatic lesion histopathologically deemed to be of prostatic origin.
* Prostate adenocarcinoma (our main focus). We will allow the inclusion of adenocarcinoma with mixed small- or large-cell neuroendocrine prostate
* Age ≥ 18 years at the time of inclusion.
* Written informed consent
* Able to understand one of the following languages sufficiently: Dutch, English, Arabic or Turkish.

Exclusion Criteria:

* Not currently living in the Netherlands.

Conditions3

CancerHigh-Risk Localized Prostate CancerSynchronous Metastatic Hormone-Sensitive Prostate Cancer

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