Copeptin Measurement After Mannitol and Hypertonic Saline for the Diagnosis of Polyuria-polydipsia Syndrome

Summary

The aim of this study is to evaluate whether a new test using mannitol infusion can diagnose the cause of polyuria-polydipsia syndrome as accurately as the current standard test (hypertonic saline infusion) and to compare which test patients prefer. The goal is to identify a simpler and more patient-friendly diagnostic approach.

Eligibility

Inclusion Criteria:

1. Age ≥ 18 years
2. Hypotonic polyuria/polydipsia syndrome defined as polyuria \>40ml/kg body weight/24h and polydipsia \>3l/24h; and urine osmolality \<800mOsm/L or known AVP-D based on accepted criteria

Exclusion Criteria:

1. Polyuria/polydipsia secondary to diabetes mellitus, hypercalcemia, or hypokalemia
2. Diagnosis of AVP-R (Copeptin \> 21.4 pmol/L)
3. Evidence of acute illness
4. Epilepsy requiring treatment
5. Uncontrolled arterial hypertension (blood pressure \>160/100mmHg at baseline
6. eGFR \< 60 ml/min/1,73 m2
7. Cardiac failure (NYHA III-IV)
8. Diagnosis of liver cirrhosis, Child-Pugh Class C
9. Uncorrected adrenal or thyroidal deficiency
10. Pregnancy or breastfeeding
11. Current or unresolved urinary obstruction
12. Enrollment in a clinical trial within the last 30 days
13. Patients refusing or unable to give written informed consent
14. Inability to follow study procedures

Conditions3

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