|

Trial Evaluating Hypo-fractionated Accelerated Versus Conventional Fractionated Adjuvant RT in Head & Neck Malignancies

RECRUITINGPhase 2/3Sponsored by All India Institute of Medical Sciences
Actively Recruiting
PhasePhase 2/3
SponsorAll India Institute of Medical Sciences
Started2026-02-10
Est. completion2028-06-30
Eligibility
Age18 Years – 80 Years
Healthy vol.Accepted
View on ClinicalTrials.gov →

NCT07573956

Summary

Hypo-fractionated radiotherapy reduces the OTT (overall treatment time) which may in turn reduce rapid accelerated repopulation of clonogenic cells during waiting period after surgery. If this holds true, there is a potential to achieve better loco-regional control in with PORT for HNSCC. There is a strong radiobiological and economic rationale for delivery hypo-fractionated radiotherapy in HNSCC. The HYPCON III trial will be aimed to reduce the number of fractions by 50% (30 fr to 15 fr)

Eligibility

Age: 18 Years – 80 YearsHealthy volunteers accepted
Inclusion Criteria:

* Patients with pT1-4 squamous cell carcinoma of oral cavity/ oropharynx/ larynx/ hypopharynx with any of the intermediate risk features:

  * Positive lymph node (s)
  * Perineural invasion
  * Lympho-vascular invasion
  * Close margins
* Age 18-80yrs
* ECOG performance status 0-1at time of surgery
* Informed consent
* Available FOR long term follow-up

Exclusion Criteria:

* High risk factors following resection: positive-margin(s)and/or extra nodal extension (ENE)
* pT1-2disease and no high-risk features (LVSI, PNI, Close margins,pN0)
* Patients receiving Neo-adjuvant or concurrent Chemotherapy
* Non-Squamous Histology
* Distant metastasis
* Synchronous or second primary malignancy outside of the oropharynx, oral cavity, larynx and hypopharynx
* Pregnant females or nursing mothers due to the probability of congenital anomalies and potential of this regimen to harm nursing infants.
* Prior Radiotherapy to head and neck region

Conditions2

CancerSquamous Cell Carcinoma Head and Neck Cancer (HNSCC)

Browse More Trials

Cancer trials

Trial data from ClinicalTrials.gov. Trial status and eligibility can change — verify directly with the study contact or on ClinicalTrials.gov.

This site does not provide medical advice. Always consult your doctor before considering enrollment in a clinical trial. Learn more on our About page.