Effects of Sedation, TEmperature and Pressure After Cardiac Arrest and REsuscitation on Major Adverse Kidney Events (STEPCARE-MAKE)

Summary

The STEPCARE-MAKE study is a predefined sub-study of the large Sedation, TEmperature and Pressure after Cardiac Arrest and REsuscitation (STEPCARE) trial, which evaluates the effects of three interventions in comatose adult patients resuscitated from out-of-hospital cardiac arrest. In this sub-study, all 3500 participants enrolled in the main trial are assessed for major adverse kidney events (MAKE) and creatinine kinetics.

Eligibility

Inclusion Criteria:

* All patients included to the main STEPCARE-trial are also included to this substudy
* Out-of-hospital cardiac arrest
* Sustained return of spontaneous circulation, defined as 20 minutes with signs of circulation without the need for chest compressions
* Unconsciousness (FOUR-score motor response \<4, inability to obey verbal commands), or being intubated and sedated due to agitation
* Eligible for intensive care without restrictions or limitations
* Inclusion within 4 hours of the return of spontaneous circulation

Exclusion Criteria:

* Out-of-hospital cardiac arrest of presumed traumatic or hemorrhagic origin
* Confirmed or suspected intracranial hemorrhage
* Pregnancy
* Extracorporeal membrane oxygenation (ECMO) prior to randomization
* No additional exclusion criteria are applied beyond those of the main STEPCARE trial

Conditions13

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