Exploring the Feasibility of an Exercise and Noninvasive Brain Stimulation Intervention in Breast Cancer Survivors

Summary

The purpose of this study is to assess the feasibility of a 4-week intervention combining exercise and transcranial alternating current stimulation (Ex+tACS) in breast cancer survivors who report experiencing cancer-related cognitive impairment. Feasibility will be assessed by measuring participant retention, adherence, satisfaction with the intervention, and safety. The researchers will also examine pre-to-post intervention changes in attention, executive function, working memory, perceived cognitive function, and physical function before, after, and four weeks post intervention completion in the Ex+tACS group compared to a control group who will receive exercise and a placebo tACS condition (CON).

Eligibility

Inclusion Criteria:

* Breast cancer survivors (≥18 years) will be eligible to participate if the following inclusion criteria is met:
* Diagnosed non-metastatic breast cancer (stages 0-3)
* Completed primary breast cancer treatment (surgery, chemotherapy, radiation) for at least 3 months
* Self-reported cognitive impairment after cancer treatment

Exclusion Criteria:

* Current participation in aerobic exercise for ≥60 min/wk
* Contraindication or impairment that precludes the potential participant from exercise as defined by the American College of Sports Medicine
* The presence of serious medical illnesses, metal implants, previous brain trauma, epilepsy or history of seizures, previous surgery to the head or spinal cord, or skin problems at the forehead area where the tACS electrodes will be applied
* Uncontrolled cardiovascular disease
* Functional impairments or physical condition that would make exercise unsafe
* Metastatic cancer or diagnosis of a different cancer (excluding melanoma) within the past 5 years
* Contraindication to exercise a defined by the American College of Sports Medicine

Conditions2

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