A First-in-Human Study to Evaluate the Safety, Pharmacokinetics and Pharmacodynamics of KUP-101A in Patients With Selected Advanced Solid Tumors

Summary

The purpose of this trial is to find the maximum tolerated and recommended Phase 2 dose of KUP-101A and to evaluate its safety and tolerability. Additionally, pharmacokinetics and pharmacodynamics will be assessed, and first data on KUP-101A's efficacy in patients with advanced solid tumors will be obtained.

Eligibility

Inclusion Criteria:

* Histologically confirmed cancer with evidence of advanced disease for which no other standard treatment is available
* ECOG Performance status of 0 to 2
* Adequate hematological, renal, and hepatic organ function

Exclusion Criteria:

* Previous systemic treatment with TLR agonists, with the exception of TLR agonists used as vaccine adjuvants.
* Known additional malignancy that is progressing or requires active treatment
* Diagnosis of immunodeficiency
* Active autoimmune disease not caused by prior anticancer treatment that required systemic immunosuppressive treatment in the past 2 years
* Active autoimmune disease caused by prior anticancer treatment, unless currently controlled by replacement therapy only.
* Any kind of leukemia
* Previously received an organ transplant (other than corneal transplants) or hematopoietic stem cell transplantation
* Known active central nervous system metastases and/or carcinomatous meningitis
* Cerebral vascular event within 6 months before Screening
* Unstable cardiopulmonary status defined by uncontrolled congestive heart failure of New York Heart Association Grade III or IV, unstable angina, or myocardial infarction within 6 months before Screening
* High grade ocular disease such as uncontrolled glaucoma

Conditions6

Interventions1

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