Clinical, Oncologic, and Metabolic Effects of Pancreatic Mass Loss After Pancreatectomy in Non-Diabetic Patients

Summary

This study will examine how removal of part or all of the pancreas affects blood sugar control, metabolism, and clinical outcomes over time. The study will include adults without diabetes before surgery who undergo pancreatic surgery as part of routine clinical care at Fondazione Policlinico Universitario A. Gemelli IRCCS. Researchers will study whether participants develop diabetes after surgery and whether this risk changes according to the type of pancreatic resection. Information from routine clinical care, metabolic tests, imaging, and pancreatic tissue samples collected during surgery may be used for research analyses.

Eligibility

Inclusion Criteria:

* Adult patients (≥18 years)
* No diabetes mellitus at baseline
* Undergoing partial, near-total, or total pancreatectomy at the study center
* Availability of clinical and metabolic data according to study component
* Written informed consent for the prospective component

Exclusion Criteria:

* Diabetes mellitus at baseline
* Age \<18 years
* Missing key clinical data precluding eligibility assessment or primary outcome evaluation
* Refusal or inability to provide informed consent for the prospective component, where applicable

Conditions5

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