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Natural History of Atrial Fibrillation-Induced Tricuspid Valve Remodeling in the Absence of Significant Tricuspid Regurgitation: A Three-Dimensional Echocardiographic Study

RECRUITINGSponsored by Centro Cardiologico Monzino
Actively Recruiting
SponsorCentro Cardiologico Monzino
Started2026-05-04
Est. completion2027-05-31
Eligibility
Age18 Years+
Healthy vol.Accepted
View on ClinicalTrials.gov →

NCT07617974

Summary

This is a prospective, observational, multicenter study aimed at characterizing tricuspid valve remodeling in patients with atrial fibrillation (AF) without significant tricuspid regurgitation (TR), in relation to AF burden progression.

Eligibility

Age: 18 Years+Healthy volunteers accepted
Inclusion Criteria:

* Consecutive patients with atrial fibrillation (paroxysmal or persistent) undergoing transthoracic echocardiography (TTE) prior to AF ablation with acquisition of a 3D TV dataset.

Eligible for enrollment in the control group will be:

1. all consecutive patients with structurally normal hearts and no history of AF or;
2. moderate atrial functional tricuspid regurgitation and AF, in the absence of significant left-sided valvular disease or prior valvular surgery.

Exclusion Criteria:

* Moderate or greater TR assessed using a multiparametric approach;
* Arrhythmias other than AF;
* Prior AF ablations;
* Rapid ventricular response (average HR \>110 bpm) during baseline TTE;
* Inadequate image quality

Conditions3

Atrial Fibrillation (AF)Heart DiseaseTricuspid Regurgitation (TR)

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