"Balance, Gait, and Motion Analysis in Multiple Sclerosis"

Summary

The goal of this observational cross-sectional study is to investigate the relationship between functional measures of balance and gait and objective kinetic and kinematic parameters in people with Multiple Sclerosis (MS). The main questions it aims to answer are: i) What is the relationship between kinetic and kinematic gait and balance parameters measured using the Vicon motion analysis system and performance on clinical functional assessments in people with Multiple Sclerosis? ii) Which biomechanical parameters are most strongly associated with functional balance, gait, and physical performance outcomes? Participants will attend a single laboratory-based assessment session. During this session, they will undergo biomechanical gait and balance analysis using the Vicon motion capture system, complete functional assessments of balance, gait, and physical performance, complete questionnaires assessing fear of falling and fatigue, and undergo assessment of lower-limb spasticity.

Eligibility

Inclusion Criteria:

* Adults (≥ 18 years) with confirmed diagnosis of Multiple Sclerosis
* Expanded Disability Status Scale (EDSS) score \<6
* Ability to ambulate independently without the use of assistive devices
* Absence of significant orthopedic or neurological conditions affecting mobility
* Ability to understand and follow verbal instructions.

Exclusion Criteria:

* History of injury or surgical intervention to the lower limbs or spine within the past year
* Any musculoskeletal, neurological, cardiovascular, or other medical condition, other than Multiple Sclerosis, that may significantly affect gait or balance or compromise participant safety during testing.
* Severe balance impairment or high risk of falling that prevents safe participation in single-leg stance, gait analysis, or obstacle negotiation tasks.

Conditions10

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