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Effect of Individualized Positive End-expiratory Pressure (PEEP) in Patients Who Have an Intrinsic PEEP During One-lung Ventilation

RECRUITINGN/ASponsored by Samsung Medical Center
Actively Recruiting
PhaseN/A
SponsorSamsung Medical Center
Started2026-08-01
Est. completion2027-05-31
Eligibility
Age19 Years – 100 Years
Healthy vol.Accepted
View on ClinicalTrials.gov →

NCT07638176

Summary

This study investigates the effects of three extrinsic PEEP settings-5 cmH2O, 0 cmH2O, and an individualized PEEP (70% of the measured intrinsic PEEP)-on intrinsic PEEP and hemodynamic stability in patients with intrinsic PEEP undergoing lung resection surgery, using a randomized, crossover design.

Eligibility

Age: 19 Years – 100 YearsHealthy volunteers accepted
Inclusion Criteria:

* American Society of Anesthesiologists Physical Status I - III
* The Eastern Cooperative Oncology Group Performance Status Grade 0 - 2
* Lung resection surgery requiring one-lung ventilation for over 60 minutes
* Indication of double-lumen endobronchial tube (female 35 Fr, male 37 Fr)
* Patient who is diagnosed with intrinsic PEEP during one-lung ventilation

Exclusion Criteria:

* Large bullae
* Emergency surgery
* Mechanical ventilation before surgery
* Hemodynamic instability before surgery
* Surgery requiring cardiopulmonary bypass
* Pregnancy, breastfeeding patient
* Patient's refusal to participate
* No intrinsic PEEP during one-lung ventilation

Conditions3

COPDLung Resection SurgeryPulmonary Disease (COPD), Chronic Obstructive

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