Lung and Heart Function Across Decades of Life in Health

Summary

The main objective of this study is to develop baseline "normal" reference values of both lung and heart function for healthy adults within the age range relevant to the United States Veteran population who served in the Southwest Asia theater of military operations. This study will involve performing key components of the Department of Veterans Affairs the Airborne Hazards and Open Burn Pit Center of Excellence (AHOBPCE) and a VA network of Post-Deployment Cardiopulmonary Evaluation Network (PDCEN) Core Clinical Evaluation in asymptomatic unexposed healthy controls without known lung or heart disease to serve as a "normal" control comparator group for veterans evaluated by PDCEN.

Eligibility

Inclusion Criteria:

* Age 24-68
* No respiratory complaints (defined as modified Medical Research Council score = 0)
* No use of respiratory medications

Exclusion Criteria:

* Non-English speaking
* Pregnancy
* BMI\>35 Kg/m2
* Tobacco smoking within prior year
* Lifetime tobacco smoking of \>5 pack-years
* Current inhaled cannabis use (any modality) \>2x weekly
* Prior inhaled cannabis uses exceeding 2x weekly within the prior year
* Illicit drug use (other than cannabis)
* No prior or current major organ disease, including but not limited to:

  * Neuromuscular weakness
  * History of malignancy (other than non-melanoma skin cancer)-- HIV/AIDS
  * Autoimmune disease
  * Solid-organ or hematopoietic stem cell transplant
  * Cardiovascular disease (other than mild HTN; \< 140/90; controlled on 2 or less medications)

    * Poorly-controlled HTN (SBP\>140 or DBP\>90 or use of more than 2 anti-hypertensive medications)
    * Any history of congestive heart failure (CHF, either HFpEF or HFrEF)
    * Any history of arrythmia (including atrial fibrillation)

Conditions5

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