Striatal and Extra-Striatal Cholinergic Terminal Density in LRRK2-PD Mutation

Summary

This study explores how a specific genetic mutation of leucine-rich repeat kinase 2 (LRRK2) affects individuals with Parkinson's disease (PD), comparing those with the mutation to others with Parkinson's disease and without the mutation (iPD). Participants will complete positron emission tomography (PET) and magnetic resonance imaging (MRI) brain imaging, cognitive tests, motor tests, sensory tests, and questionnaires. The aims of this study are to compare brain chemicals in LRRK2 PD patients with iPD patients and to correlate brain chemicals with motor and cognitive tests in LRRK2 PD and iPD patients.

Eligibility

Inclusion Criteria:

1. Male or Female, age 45 years and over.
2. Diagnosis of PD based on the United Kingdom Parkinson's Disease Society Brain Bank Diagnostic Research Criteria (Hughes et al., 1992).
3. Presence of LRRK2 mutation as confirmed by referral from UM Movement Disorders clinic, medical record review, or participation in the PDGENEration study.

Exclusion Criteria:

1. Evidence of atypical parkinsonism.
2. Contra-indications to MR imaging including but not limited to pacemakers, aneurysm clips, intraocular metal, cochlear implant, or severe claustrophobia.
3. Evidence of large vessel stroke or mass lesion on MRI.
4. Regular use of typical anti-cholinergic drugs or cholinesterase inhibitors.
5. History of deep brain stimulation surgery.
6. Pregnant or nursing.
7. Suicidal ideation, as indicated by a response of 2 or 3 on question 9 of the Beck Depression Inventory.
8. Cognitive impairment that results in the inability to give consent, as demonstrated by the Decision Making Capacity Tool.
9. Any other condition or criterion that would preclude safe and meaningful participation in the study.

Conditions2

Locations1 site

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