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Dietary Tracking in Heart Failure

RECRUITINGSponsored by The Cleveland Clinic
Actively Recruiting
SponsorThe Cleveland Clinic
Started2026-06
Est. completion2036-06
Eligibility
Age18 Years+
Healthy vol.Accepted
Locations1 site

Summary

Emerging evidence links ultra processed foods (UPFs) to adverse cardiovascular outcomes. UPFs are often high in sodium, unhealthy fats and added sugars, while being low in essential nutrients and fiber. UPFs contribute to systemic inflammation, fluid retention, and metabolic dysfunction-key drivers of HF and kidney disease progression. Traditional dietary counseling often lacks specificity around food processing levels. Furthermore, the majority of nutrition studies relied on extensive self-reported dietary recall food frequency questionnaires (FFQ) that are subjective, often labor intensive, and difficult to implement practically in the clinical setting. As such, researchers have developed metabolite scores from blood and urine samples to help quantify UPF consumption, which has the promise to better guide dietary counseling and track process. Therefore, the aim of this study is to evaluate the feasibility and physiological impact of a structured UPF-reduction dietary intervention in patients with HF, leveraging both digital dietary tools (Cronometer) and biomarker assessments.

Eligibility

Age: 18 Years+Healthy volunteers accepted
Inclusion Criteria:

* Adults (≥18 years) with NYHA Class II-III HF
* Able to use Cronometer to track dietary intake and able to prepare food at home independently (able to modify dietary intake)

Exclusion Criteria:

* History of heart transplant or LVAD implant
* Unable or unwilling to follow dietary coaching for UPF reduction
* eGFR \<30 ml/kg/1.73m2

Conditions4

Heart DiseaseHeart FailureNYHA Class II Heart FailureNYHA Class III Heart Failure

Locations1 site

Cleveland Clinic Main Campus
Cleveland, Ohio, 44195
Valesha Province, MS216-636-6153provinv@ccf.org

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