Toxin Exposure and Immune Dysregulation in Non-Hodgkin Lymphoma

Summary

The goal of this observational cohort study is to learn how toxin and occupational exposures, germline genetic variation, and immune dysregulation relate to B-cell non-Hodgkin lymphoma among active-duty service members and other Military Health System beneficiaries. The main questions are whether specific exposures and germline variants are associated with B-cell NHL subtype, immune dysfunction, and clinical outcomes. Participants will complete exposure and medical-history surveys, provide biospecimens for immune and genomic testing, and may be followed annually for up to 3 years.

Eligibility

Inclusion Criteria:

* Age 4 years old and older with a clinical diagnosis of B-cell NHL.
* Must be willing to undergo phlebotomy and/or skin punch biopsy.
* Must be willing to undergo whole genome sequencing, which includes return of primary and secondary findings.

Exclusion Criteria:

* Has any condition that, in the opinion of the Principal Investigator, contraindicates participation in this study. Examples of situation that may contraindicate participation include but are not limited to a) some cases of cerebral vascular accidents where an individual no longer has the capacity to make their own medical decisions and a conservator or responsible family member is not available and b) an individual has active suicidal ideation and is a danger to themselves at the time of enrollment.
* Does not have access to health care and primary care clinician.
* Actively undergoing induction treatment for NHL.

Conditions5

Locations3 sites

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