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Coeliac Plexus vs Splanchnic Nerve Neurolysis for Upper Abdominal Cancer Pain

RECRUITINGN/ASponsored by Bangladesh Medical University
Actively Recruiting
PhaseN/A
SponsorBangladesh Medical University
Started2026-05-01
Est. completion2026-10-30
Eligibility
Age18 Years+
Healthy vol.Accepted
View on ClinicalTrials.gov →

NCT07653906

Summary

The goal of this clinical trial is to determine whether Neurolytic Splanchnic Nerve Block (NSNB) reduces pain in adults with upper abdominal malignancies. It will also evaluate the safety of Neurolytic Splanchnic Nerve Block (NSNB). The main questions it aims to answer are: Does NSNB reduce pain intensity compared to Neurolytic Coeliac Plexus Block (NCPB), as measured by the Visual Analog Scale (VAS)? What adverse effects do participants experience when receiving Neurolytic Splanchnic Nerve Block (NSNB)? Investigators will compare Neurolytic Splanchnic Nerve Block (NSNB) with Neurolytic Coeliac Plexus Block (NCPB) to determine which intervention provides more effective and safer pain relief. Participants will: * receive either NSNB or NCPB under fluoroscopic guidance * be monitored immediately and for 2 hours after the procedure for any complications Have their pain intensity recorded immediately after the procedure, and at 7 days, 1 month, and 3 months * be evaluated for quality-of-life using European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire - Core 3 (EORTC QLQ-C30) at 1 month and 3 months. * have their opioid consumption tracked throughout the study.

Eligibility

Age: 18 Years+Healthy volunteers accepted
Inclusion Criteria:

* Adult patient
* Both genders
* Diagnosed case of upper abdominal malignancy (pancreatic, gastric, hepatic, or biliary origin)
* Experiencing moderate to severe pain (≥5 on a 10 point visual analog scale)
* Patients who are conscious and can communicate
* No Contraindication for nerve block (e.g., coagulopathy, anticoagulant drugs)

Exclusion Criteria:

* Previous coeliac plexus block, splanchnic nerve block, or major abdominal nerve ablation
* Severe spinal deformities or anatomical distortion at the coeliac plexus or splanchnic nerve site
* Local or systemic infection at or near the block site
* Known allergy to local anesthetics or neurolytic agents
* Pregnancy
* Lactating mother
* Cognitive impairment or psychiatric illness

Conditions4

Abdominal NeoplasmsCancerNeurolytic TechniquesPain Management

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