Predictive Value of Tumor Microenvironment PET/CT for Response and Prognosis in Aggressive Lymphoma: A Multicenter Study

Summary

This multicenter study aims to evaluate the predictive value of tumor microenvironment PET/CT imaging for treatment response and prognosis in patients with aggressive lymphoma. Eligible patients with histologically confirmed aggressive lymphoma will undergo FAPI PET/CT imaging, and selected patients who are candidates for immunotherapy will undergo Grazytracer PET/CT imaging. These imaging methods are intended to assess fibroblast activation protein expression and granzyme B activity in lymphoma lesions, reflecting cancer-associated fibroblasts and cytotoxic T-cell activity in the tumor microenvironment. The study will explore optimal imaging assessment criteria and develop clinical-pathological-imaging models to predict treatment response, prognosis, and the relationship between tumor heterogeneity and refractory or relapsed disease.

Eligibility

Inclusion Criteria:

* Histologically confirmed aggressive lymphoma.
* Baseline PET/CT showing moderate to high FDG uptake in lymphoma lesions.
* No previous history of malignant tumors.
* No significant cardiac, hepatic, or renal dysfunction.
* Expected survival of at least 6 months and ability to complete follow-up.

Exclusion Criteria:

* Low FDG uptake on baseline PET/CT.
* Lymphoma lesions have been surgically removed, with no positive lesions available for evaluation.
* Active or uncontrolled chronic inflammation or infection.
* Uncontrolled diabetes mellitus.
* Incomplete clinical data or loss to follow-up.
* Refusal to sign the informed consent form.
* Inability to lie supine for 30 minutes.

Conditions2

Interventions2

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