Intraarticular Injection of Botox and Hyaluronic Acid in Knee Osteoarthritis

Summary

This study aims to compare the efficacy of intra-articular injection of Botulinum toxin and hyaluronic acid on pain in knee osteoarthritis.

Eligibility

Inclusion Criteria:

* Age ≥ 50 years.
* Both genders.
* Chronic knee osteoarthritis (KOA) according to American College of Rheumatology criteria for the diagnosis of knee osteoarthritis.
* Third or fourth grade Kellgren and Lawrence system for classification of osteoarthritis based on radiological data, it is a common method of classifying the severity of osteoarthritis (OA) using five grades according to the following sites and projections.

Exclusion Criteria:

* History of intra-articular injection within the last 6 months,
* History of surgery on the knee joint or major trauma to the lower limb causing fracture.
* Body mass index (BMI) more than 40 kg/m2.
* Medical conditions affecting the joint or lower extremity function such as severe osteoporosis, rheumatoid arthritis, collagen vascular diseases, and gout.
* Diabetic patient.
* Any contraindication to intra-articular injections for instance immunodeficiency, coagulation defect or anticoagulation therapy taking or skin infection at the site of injection.
* Hypersensitivity to Botulinum toxin or hyaluronic acid.

Conditions5

Interventions2

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